منابع مشابه
Nucleoside-Sparing Regimens With Raltegravir and a Boosted Protease Inhibitor: An Unsettled Issue.
training of site staff, the ability to manage a large volume of tests in clinics with a large patient population, and the potential lack of quality control, especially when used in more remote settings, where the technology could have the greatest impact. Nevertheless, the prospect of a potentially simpler, cheaper, and more patient-centered care model is appealing, and studies looking at the i...
متن کاملCorticosteroid and calcineurin inhibitor sparing regimens in kidney transplantation.
Chronic kidney disease is a major public health problem that is associated with increased risks of kidney disease progression, cardiovascular disease and death. Kidney transplantation remains the renal replacement therapy of choice for patients with end-stage kidney disease. Despite impressive strides in short-term allograft survival, there has been little improvement in long-term kidney graft ...
متن کاملMeta-analysis of calcineurin-inhibitor-sparing regimens in kidney transplantation.
Calcineurin-inhibitor-sparing strategies in kidney transplantation may spare patients the adverse effects of these drugs, but the efficacy of these strategies is unknown. Here, we conduct a meta-analysis to assess outcomes associated with reducing calcineurin inhibitor exposure from the time of transplantation. We search Medline, Embase, and Cochrane Register of Controlled Trials for randomized...
متن کاملProtease inhibitor-sparing simplified maintenance therapy: a need for perspective.
Body fat changes and metabolic abnormalities such as hyperlipidaemia and diabetes have been increasingly reported following the successful introduction of highly active antiretroviral therapy (HAART). These side effects were attributed initially to the use of protease inhibitors (PIs). As a consequence, a series of trials were conducted where patients with well-controlled HIV viraemia either co...
متن کاملMetabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment.
BACKGROUND The metabolic effects of initial therapy for HIV-1 infection are important determinants of regimen selection. METHODS Open-label study in 753 subjects randomized equally to efavirenz or lopinavir/ritonavir(r) plus two nucleoside reverse-transcriptase inhibitor (NRTI) vs. the NRTI-sparing regimen of lopinavir/r plus efavirenz. Zidovudine, stavudine, or tenofovir with lamivudine was ...
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ژورنال
عنوان ژورنال: Journal of the International Association of Physicians in AIDS Care
سال: 2002
ISSN: 1545-1097
DOI: 10.1177/154510970200100402